Query 10-22b: The effects of Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Ankylosing Spondylitis (AS)


Ankylosing spondylitis (AS) is a chronic, progressive, inflammatory type of arthritis that affects up to 1 percent of Canadians. Therapy options are limited, especially for patients with active and severe disease. Nonsteroidal anti-inflammatory drugs (NSAIDs, e.g. Naproxen) are used along with disease-modifying anti-rheumatic drugs (DMARDs, e.g. methotrexate).


Unfortunately there is relatively little published evidence to help physicians and their patients choose which DMARDs to use in which AS patients, under which circumstances. In this catalyst grant, we based our analyses on data prospectively collected on patients enrolled in a large AS patient cohort.

The main clinical outcomes are measured by validated measures of disease activity, functional limitation, and quality of life. Data on infections requiring hospitalizations are being used to evaluate safety.


We have submitted a manuscript of our results and have presented the results at the Canadian Rheumatology Association (CRA) meeting in Quebec City, Quebec in February 2015, and the EUropean League Against Rheumatism (EURLA) meeting in Rome, Italy in June 2015.


Moura C, Rahme E, Maksymowych W, Abrahamowicz M, Bessette L, Bernatsky S. Current use of non-biologic DMARDs or anti-TNF agents were not associated with increased risk of hospitalized infections in ankylosing spondylitis (AS). Submitted and under review at Arthritis Research & Therapy.


Moura CS, Rahme E, Maksymowych WP, Abrahamowicz M, Bessette L, Bernatsky S.  Persistence of Anti-TNF and DMARD use in a Population-Based Sample of Ankylosing Spondylitis (AS) in Quebec. Canadian Rheumatology Association (CRA) Annual Scientific Meeting. Quebec City, Canada. 4-7 February 2015.


Moura CS, Rahme E, Maksymowych WP, Abrahamowicz M, Bessette L, Bernatsky S. Risk of Hospitalized Serious Infection in Ankylosing Spondylitis (AS) Patients Using nbDMARD or Anti-TNF. Annual European Congress of Rheumatology EULAR. Rome, Italy. 10-13 June 2015.



For more information contact: Autumn Neville. Research Coordinator. autumn.neville@rimuhc.ca   514.934.1934 ext.44844  or  514.699.4828

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