{"id":538,"date":"2014-05-20T21:06:52","date_gmt":"2014-05-20T21:06:52","guid":{"rendered":"http:\/\/phpstack-231187-803904.cloudwaysapps.com\/?page_id=538"},"modified":"2019-04-05T13:23:01","modified_gmt":"2019-04-05T13:23:01","slug":"can-aim-demonstration-project","status":"publish","type":"page","link":"https:\/\/canaim.ca\/can-aim-demonstration-project\/","title":{"rendered":"CAN-AIM Demonstration Project"},"content":{"rendered":"

W<\/span>e have carried out the CAN-AIM \u2018demonstration project\u2019 on \u2018Comparative Effectiveness of anti-Tumor Necrosis Factor agents versus traditional Disease-Modifying agents in reducing orthopedic surgery in rheumatoid arthritis.<\/h2>\n

A manuscript, that summarizes these results,\u00a0was published\u00a0to the peer-reviewed journal Arthritis Care and Research<\/em> in August 2015. <\/a>The article is one of the journal’s most highly accessed articles<\/strong>.\u00a0We analyzed a cohort of new-onset RA patients, identified from Quebec\u2019s physician billing and hospitalization databases from 2002-2008; who were beneficiaries of the provincial drug plan.<\/p>\n

We also presented results at the EUropean League Against Rheumatism (EULAR) meeting in\u00a02014 <\/a>in Paris, France and at EULAR\u00a02015\u00a0<\/a>in Rome, Italy.<\/p>\n

Their data were linked to the pharmacy dispensation database. We used a series of multivariable Cox regression models with time-dependent variables representing alternative measures of cumulative effects of past use of: 1) methotrexate (MTX), and 2) other disease-modifying anti-rheumatic drugs (DMARDs), quantified over different time windows. In parallel with the Quebec analyses, we have been working on similar datasets from Manitoba, Nova Scotia, Ontario, and British Columbia.<\/p>\n

This involved considerable efforts necessary to clean the data, as well as to homogenize variables definitions and analytical methods across the 5 provinces. We have finalized the data cleaning and coding programs for each province.<\/p>\n

We have published a second manuscript in the Journal of Rheumatology which also looks at Ontario.<\/a>\u00a0Results suggest that longer exposure to methotrexate or other DMARDs within the first year after RA diagnosis is associated with longer time to joint replacement surgery<\/p>\n

Overall, the demonstration project confirmed the CAN-AIM team\u2019s abilities and skills in both (i) using advanced methodology to address a challenging issue regarding drugs\u2019 effectiveness and (ii) efficient and productive networking\/collaboration of investigators, research trainees and staff from 5 provinces.<\/p>\n","protected":false},"excerpt":{"rendered":"

We have carried out the CAN-AIM \u2018demonstration project\u2019 on \u2018Comparative Effectiveness of anti-Tumor Necrosis Factor agents versus traditional Disease-Modifying agents in reducing orthopedic surgery in rheumatoid arthritis. A manuscript, that summarizes these results,\u00a0was published\u00a0to the peer-reviewed journal Arthritis Care and Research in August 2015. The article is one of the journal’s most highly accessed articles.\u00a0We … Continue reading “CAN-AIM Demonstration Project”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/pages\/538"}],"collection":[{"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/comments?post=538"}],"version-history":[{"count":0,"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/pages\/538\/revisions"}],"wp:attachment":[{"href":"https:\/\/canaim.ca\/wp-json\/wp\/v2\/media?parent=538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}