May 26, 2016

Progress with innovations to CATCH EDC – Rapid Funding for DSEN Cont’d

This project aims to build capacity for drug safety and effectiveness research in rheumatoid arthritis (RA) in Canada. Funding has allowed enhancement of a very large and well-established Canadian multicenter RA cohort. RA affects 1% of Canadians and is associated with very high morbidity, mortality, and economic burden. Aggressive treatment is believed to optimize outcomes.

Our first project was a study comparing therapy persistence for different methotrexate-based treatments. We built a modern and flexible electronic data capture (EDC) system enabled for real-time data entry within the clinical encounter. The EDC system supports multiple devices and platforms (e.g. desktop, tablet, mobile phones, IOS, Android etc.). All sites are provided with one or more tablets for data entry. The EDC program also allows for:

  • Within form and cross-form real-time data logic checks
  • Forward propagation and adaptive form customization based on previously entered fields.
  • Embedded data query system for centralized tracking and management of missing data
  • Automated withdrawal forms recording reasons for withdraw
  • Automated study visit scheduler with push electronic reminders. For use by site personnel to notify patients of upcoming appointments as well as when/ which study forms to complete.
  • Dynamic data entry to capture medication adjustments /switches and patient flares that may occur between protocolized visits
  • Ability to easily upload scanned lab and imaging reports
  • Customizable physician dashboard to review patient summaries of clinical and prognostic indicators to help support medical decision making

CATCH continues to provide support to sites with the transition to electronic data entry.

Presentations:

Kerbachi M, et al. Incidence of Infections in Early Arthritis. Poster presented at:  Canadian Rheumatology Association Annual Scientific Meeting; February 21-24, 2018; Vancouver, CA.

Moura CS, et al. Methotrexate Treatment Strategies in an Early Rheumatoid Arthritis Cohort. Poster presented at:  Canadian Rheumatology Association Annual Scientific Meeting; February 21-24, 2018; Vancouver, CA.

Moura CS, et al. Additions to Methotrexate with Conventional and Biologic DMARDs in Rheumatoid Arthritis: Are There Differences in Subsequent Time to Treatment Failure? Poster presented at:  Canadian Rheumatology Association Annual Scientific Meeting; February 21-24, 2018; Vancouver, CA.

Bernatsky S, et al. Additions to Methotrexate with Conventional and Biologic Dmards in Rheumatoid Arthritis: Are There Differences in Subsequent Time to Treatment Failure?  Poster presented at:  American College of Rheumatology/ Association of Rheumatology Health professionals (ACR/ARHP) Annual Scientific Meeting; November 3-8, 2017; San Diego, CA.

Bernatsky S, et al. Methotrexate Treatment Strategies in an Early Rheumatoid Arthritis Cohort.  Poster presented at: American College of Rheumatology/ Association of Rheumatology Health professionals (ACR/ARHP) Annual Scientific Meeting; November 3-8, 2017; San Diego, CA.

Kerbachi M, et al. Incidence of Infections in Early Arthritis. Poster presented to: American College of Rheumatology/ Association of Rheumatology Health professionals (ACR/ARHP) Annual Scientific Meeting; November 3-8, 2017; San Diego, CA.

Publications:

Moura CS, et al. Treatment strategies in early rheumatoid arthritis methotrexate management: Results from a prospective cohort. Arthritis Care & Research 2019 May 21. doi: 10.1002/acr.23927.

For more information contact: Autumn Neville, Research Coordinator. autumn.neville@rimuhc.ca