Q# 16-09: Fluconazole and Risk Fetal Events during Pregnancy
This project aims to investigate the association between use of fluconazole, a systemic azole antifungal drug treating vulvovaginal candidiasis, during pregnancy and the risk of spontaneous abortion, still birth or major birth defects/congenital malformations and under what conditions these situations occur (timing [first, second or third trimester, or throughout pregnancy], dosing [single 150 mg or less fluconazole dose, cumulative dosing]).
A full report for this query was prepared.
Berard A, et al. Risk of oral low and high dose fluconazole use during pregnancy: 3 nested case-control studies in the Quebec Pregnancy Cohort. 2018. Manuscript accepted to CMAJ.