Hydroxychloroquine: Enthusiasm for a potential COVID cure affects patients

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can potentially lead to serious organ complications and even death. Its global burden, in terms of economic costs and capacity to compromise health-related quality of life, is huge. Hydroxychloroquine (HCQ) is one of the safest, most effective drugs for SLE, and is used by almost every SLE patient in North America. At the start of the COVID-19 pandemic, the unprecedented public and scientific optimism for HCQ as a potential treatment created urgent concern about shortages of this inexpensive medication, which is such a cornerstone of SLE therapy. CAN-AIM members Dr. Evelyne Vinet, Dr. Arielle Mendel, and Dr. Sasha Bernatsky (McGill) quickly organized both a national and an international survey of rheumatologists to learn about their experience of HCQ shortages. The results, published in Annals of the Rheumatic Diseases in May and June, reveal that a majority of respondents reported difficulties in accessing or renewing the drug. https://pubmed.ncbi.nlm.nih.gov/32586918/

The problem was much more apparent in Quebec, where 90% of rheumatologists reported HCQ access issues. This was potentially an unintended consequence of provincial regulators to tightly control HQN prescriptions. That unfortunately affected patients with SLE as well as other rheumatic diseases (e.g. rheumatoid arthritis, RA, affecting 1% of Canadians). The international survey revealed similar problems in Europe and the USA, though respondents from four countries (Sweden, Denmark, Singapore, South Korea) reported no HCQ access issues. https://pubmed.ncbi.nlm.nih.gov/32434820/ Drs. Mendel, Vinet and Bernatsky have since established the CAnadian Network for REsearch on COVID-19 in Rheumatology (CAN-RECOVR https://canrecovr.wordpress.com/) to better understand how the pandemic affects rheumatic disease care. This collaborative network will connect Canadian rheumatology researchers to study priority COVID-related questions, with harmonized data collection. One project led by Drs. Mendel and Vinet is the study of thrombotic risk related to antibody production, using the Quebec COVID-19 biobank.

Evidence-based COVID Decision-making Starts in Canada’s Emergency Departments

As an emergency physician, CAN-AIM researcher Dr. Corrinne Hohl (UBC) is a ‘front line’ care provider for some of the very sickest COVID patients. While COVID was rapidly emerging as the greatest public health threat in a century, she was struck by the gaps in knowledge concerning emergency care. Spurred on by this, she is leading investigators from 51 emergency departments across 8 Canadian provinces to conduct a CIHR-funded multi-centre national cohort study. This cohort study is enrolling patients presenting consecutively to ERs with suspected COVID. Standardized prospective data will be collected and linked to electronic patient records to provide answers about key outcomes such as COVID test results, hospitalization, ICU stay, ventilation requirements, mortality, discharge safety, and other patient-centred data.

The results will be used to develop and validate clinical decision rules regarding patients presenting with suspected COVID. This will subsequently allow personalized evidence-based recommendations to improve COVID treatment (and outcomes) right from the time of presentation. https://canadiancovid19ednetwork.org/ Given the difficulty that every nation on the planet has had generating evidence for guiding COVID treatment, this study will not only have long-lasting impact on guidelines in Canada, but may also inform international guidelines as well. As an added value, this new project will form the basis for an enduring national network of collaboration to optimize COVID treatment in Canada. It is anticipated that this network will generate 30-50 sub-studies of high relevance to the Canadian pandemic response.

CONCEPTION: Short- and long-term impact of COVID-19 public health guidelines and hospital policies on maternal and child mental and physical health

As a long-time CAN-AIM researcher and the director of its pillar on drug safety in pregnancy and offspring, Dr. Anick Berard (Sainte-Justine Research Centre researcher and full professor at the Université de Montréal) is dedicated to providing clinicians, patients, and regulators with the data they need to optimize health outcomes. Science has already established that major stressful episodes can have a big impact on pregnancy, the physical and mental health of pregnant women, and even on the children of mothers who were pregnant during these traumatizing events. Always at the cutting edge, Dr. Berard has now launched an international, multi-province, and multi-university COVID research initiative called CONCEPTION, to tackle key knowledge gaps. The scientific team from Canada, the United States, and Europe will assess how measures such as confinement, physical distancing, school closures, quarantine and restrictions on companions during medical appointments and labor have physical and mental health impact on expecting mothers and their babies.

CONCEPTION builds on existing collaborations and infrastructures in Canada and abroad. Pregnant women are being recruited via a social media campaign with online collection of epidemiologic data (at recruitment and at 2 months post-partum), with data linkage to the ongoing longitudinal multi-provincial Canadian Mother-Child Cohort (CAMCCO) Active Surveillance Initiative (built with province-specific administrative, hospital and birth certificate data linkage, supported by CIHR and the Canadian Foundation for Innovation). https://research.chusj.org/en/Communications/Nouvelles/2020/Projet-CONCEPTION-Debut-d-une-vaste-etude-pour-m. The study was launch on social media in June and intend to recruit 5,000 eligible pregnant women from Canada, USA, France, Austria, Denmark, Sweden, and the Emirates, of which 4,239 who have been recruited and completed the baseline questionnaire. CONCEPTION provides a timely portrait of the consequences of COVID-related public health decisions and changes in the provision of healthcare during the peri- and post-natal period, as well as the effect of the unprecedented public health crisis on pregnant and post-partum women and newborns.