Ondansetron and fetal abnormality

Q# 16-08: Ondansetron and Fetal Abnormality

This project aims to investigate the association between use of ondansetron in pregnancy and the risk of fetal abnormalities. We identified 50,269 pregnancies with antiemetic medications exposure during pregnancy:  54 pregnancies exposed to ondansetron, 49,885 pregnancies exposed to pyridoxine/doxylamine, and 1,735 pregnancies exposed to metoclopramide. Results indicated increased risk of major congenital malformation comparing pregnancies exposed to antiemetic medications during the 1st trimester to the unexposed group (adjusted odds ratio – aOR: 1.07; 95%CI: 1.03-1.11). When the antiemetic medications were analysed separately, we found higher risk associated with pyridoxine/doxylamine (aOR: 1.07; 95%CI: 1.03-1.11) and metoclopramide (aOR: 1.27; 95%CI: 1.03-1.57); the risk for pregnancies exposed to ondansetron was lower (aOR: 0.57), but the result was not statistically significant (95%CI: (0.13-2.49). Similar trends were observed for exposure at any point during the pregnancy.

Full results of this analysis were presented in a separated report in June 2017.

A manuscript of the results is under review by the Journal of Clinical Epidemiology.

For more information contact: Autumn Neville. Research Coordinator. [email protected]   514.934.1934 ext.44844 or ext.44718

Options for appropriate prescribing

Query# 16-07: Options for appropriate prescribing

This project aims to conduct a review of interventions to support appropriate prescribing of opioid. A full report was submitted to DSEN describing the results from the systematic review and an abstract with a summary of the review was presented at the 33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management.

Phase 1 of this project, a systematic review, has been completed. After discussions with Health Canada, it was determined that Phase 2 be made into its own separate query.

Moride et al. A systematic review of interventions and programs targeting appropriate prescribing of opioids. 2017 (ICPE abstract)

Moride et al. A systematic review of interventions and programs targeting appropriate prescribing of opioids. 2018. Manuscript accepted to the Pain Physician Journal.

For more information contact: Autumn Neville. Research Coordinator. [email protected]   514.934.1934 ext.44844  or  ext.44718

Use of social media and crowd sourcing data analytics to increase drug safety and public awareness

Query# 16-01: Use of social media and crowd sourcing data analytics to increase drug safety and public awareness

The objective of this study is to assess the value of using social media surveillance for pharmacovigilance in Canada. Analysis is currently underway and a discussion of preliminary results with Health Canada was held in December 2018. Health Canada’s input will lead to revisions of the preliminary report. 

For more information contact: Autumn Neville. Research Coordinator. [email protected]   514.934.1934 ext.44844  or  ext.44718