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Developing novel methods to study drug safety and effectiveness
514.934.1934 ext.44844
McGill University Health Centre

Response to Specific DSEN Queries

09
Aug

Q# 16-08: Ondansetron and Fetal Abnormality   This project aims to investigate the association between use of ondansetron in pregnancy and the risk of fetal abnormalities. We identified 50,269 pregnancies with antiemetic medications exposure during pregnancy:  54 pregnancies exposed to ondansetron, 49,885 pregnancies exposed to pyridoxine/doxylamine, and 1,735 pregnancies exposed to metoclopramide. Results indicated increased […]

09
Aug

Query# 16-07: Options for appropriate prescribing   This project aims to conduct a review of interventions to support appropriate prescribing of opioid. Previously, a full report was submitted to DSEN describing the results from the systematic review and an abstract with a summary of the review was presented at the 33rd International Conference on Pharmacoepidemiology […]

09
Aug

Query# 16-01: Use of social media and crowd sourcing data analytics to increase drug safety and public awareness   The objective of this study is to assess the value of using social media surveillance for pharmacovigilance in Canada. The platform installation and training has been completed and the protocol is being developed for the evaluation […]

11
Aug

Query 16-03: Preventable adverse drug reactions (ADR) as percentage of total ADRs   This project was funded in June 2016 for two years. The query will be addressed in two phases: i) in phase I, we will conduct a retrospective chart review of patients diagnosed with an ADE to determine the preventability of the event, […]

11
Aug

Query 15-11: Intravitreal bevacizumab for retinal conditions: real-world safety assessment   This project was originated with a query by CADTH and funded in June 2016 for one year. The objective of this study is to examine ocular complications of anti-VEGF injections given for neovascular age-related macular degeneration (AMD) and other retinal conditions in population-based cohorts.   […]

11
Aug

Query 11-03: How do thiazide diuretics compare to ACE inhibitors and combination antihypertensive products in terms of effectiveness (and cost-effectiveness) for the management of hypertension in non-diabetic patients?   This project, which originated with a query by British Columbia Ministry of Health, was funded in 2013 for 3 years. Initial results have been generated and discussed […]

26
May

Drs. Sasha Bernatsky and Louise Pilote received funding from the Drug Safety and Effectiveness Network (DSEN) Rapid Funding for DSEN Targeted Research to continue developing novel methods using prospective longitudinal cohorts and responding to key knowledge gaps regarding drug safety and effectiveness through the Enhanced Cohort project.   Research Project Title: Canadian Early Arthritis Cohort […]

20
May

Query 10-22b: The effects of Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Ankylosing Spondylitis (AS)   Ankylosing spondylitis (AS) is a chronic, progressive, inflammatory type of arthritis that affects up to 1 percent of Canadians. Therapy options are limited, especially for patients with active and severe disease. Nonsteroidal anti-inflammatory drugs (NSAIDs, e.g. Naproxen) are used along with […]

20
May

Query 12-10: Newer antidepressants and Persistent Pulmonary Hypertension of the Newborn (PPHN) This project was funded (by CIHR-DSEN, as a query posed by Health Canada) on November 2013 for one year (Nominated PI A. Berard, co-PI S. Bernatsky, co-investigator M. Abrahamowicz). In our analyses, we used data from three pre-established pregnancy cohorts (Quebec, Saskatchewan and […]

20
May

Query 13-01: Darunavir and congenital malformations This project was funded (by CIHR-DSEN, as a query posed by Health Canada) in August 2013 for one year (PI: A. Berard, co-PI S. Bernatsky, co-investigator M. Abrahamowicz). In our analyses, we used data from three pre-established pregnancy cohorts (Quebec, Saskatchewan and US Medicaid). Results indicated that antiretroviral use […]

20
May

Query 11-04: How does real world use of insulin glargine compare to NPH insulin in terms of effectiveness and safety (and ideally cost-effectiveness) for the management of type 1 diabetes mellitus? What is the comparative effectiveness and safety of sitagliptan and NPH insulin for the management of type 2 diabetes (T2D) not controlled by metformin […]

20
May

This project, that originated with a query by Health Canada, was funded in March 2013 (PI: Sasha Bernatsky) and is already completed.   To respond to this query, our team ensured access to the CaMos (Canadian Multicentre Osteoporosis Study) database.   We presented preliminary results at the CAPT Conference in November 2013. Moura C, Bernatsky […]

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