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Developing novel methods to study drug safety and effectiveness
514.934.1934 ext.44844
McGill University Health Centre

CAN-AIM Committee Structure

CAN-AIM Committee Structure

Committee Responsibilities
  • CAN-AIM Committee Structure
Oversight Committee
  • Coordinate the activities of the other committees
  • Receive DSEN queries
  • Be responsible for the timely production and the scientific content of responses provided to DSEN
  • Produce yearly progress reports and the final report for DSEN
  • Review and approve potential queries originated from the Network investigators
  • Determine the general strategy for budget allocation
  • Consultation with the Clinical Expertise and Data Access committees, decide on future expansions of the Network, to include other investigators
Data Access Committee
  • Develop and continuously update the registry of administrative and clinical databases and on-going cohorts that may be used to respond to different queries, involving various clinical populations
  • Inform the OVERSIGHT committee and the Network members of new opportunities in terms of newly available data or recently initiated cohorts
  • Identify particular data sources that will be employed in a specific query
  • Identify (where possible) smaller cohorts, with richer clinical data, to enhance the main analyses
Study Design Committee
  • In coordination with DATA ACCESS, CLINICAL EXPERTISE and DATA ANALYSIS committees, determine the design of each prospective study to be carried out by the Network
  • For each particular study, develop standardized study protocols, data collection and data quality assessment procedures, and data entry forms to be used by all the participating centres
  • Educate the Network members about new scientific developments in the area of study designs and epidemiological methods appropriate for comparative effectiveness research (CER) studies
Clinical Expertise Committee
  • Monitor newly published randomized control trials (RCT) and on-going RCT’s, as well as case reports to identify potential high-priority queries regarding comparative effectiveness and/or safety of specific drugs;
  • Initiate and provide an oversight for the review of clinical publications relevant for specific queries
  • Decide about future expansions of the Network to ensure specific substantive expertise, necessary to address a particular query, and identify Canadian experts in these areas of expertise
  • For each specific query, provide substantive expertise necessary to design a given study, decide what data have to be collected etc., and help interpreting the results
  • Together with DATA ANALYSIS and STUDY DESIGN committees, provide substantive, clinical expertise for interpretation of the results and identification of potential study limitations
Data Analysis Committee
  • Monitor statistical and epidemiological literature to identify new methodological developments relevant to the analysis of CER studies
  • Together with the COMMUNICATION & KT committee, organize teleconferences, workshops and other educational activities to promote the use of state-of-the-art statistical methods in CER
  • For each specific query, develop – together with DATA ACCESS, CLINICAL EXPERTISE and STUDY DESIGN committees – a detailed analysis strategy (including sensitivity analyses, possible post hoc exploratory analyses, formal procedures for hypothesis testing etc.), and standardized data analysis protocols, to be used by all the participating centers
  • Supervise all activities related to statistical analyses and statistical software implementation
  • Provide methodological expertise necessary to interpret the results for specific queries
  • Identify – whenever necessary – un-resolved methodological issues (e.g. related to specific limitations of the available data) that may affect the validity or accuracy of the proposed analyses and, if so, initiate, design and supervise methodological sub-studies (e.g. simulation studies) to assess and/or reduce the impact of such limitations;
  • Inform the TRAINING committee about priorities, in terms of allocation of the training-oriented portion of the budget, for training graduate students in specific methodologies and/or the need to identify trainees or new investigators with particular cutting-edge methodological expertise.
Internal Communication/Networking & KT Committee
  • Oversee internal networking activities, and links of our team with the DSEN and other stakeholders
  • Coordinate external knowledge translation and exchange activities
  • Work through DSEN channels to provide directed communications to decision-makers and other stakeholders, including professional associations, government bodies, and patient advocacy groups
  • Oversee creation and management of a dedicated website
  • Oversee regular teleconferences and meetings between our team and relevant policy-makers
  • Collect input from these stakeholder groups to tailor information to the users
Capacity Building Committee
  • Allocate the budget for training to specific centers and areas of expertise
  • Organize and supervise training activities
  • Stimulate inter-disciplinary and inter-university training activities, including co-supervision
  • Identify the opportunities for graduate students to have hands-on involvement in the Network activities, including both literature review and data management and analyses
  • Together with the COMMUNICATION & KT committee, promote KT activities by the participating trainees

 

 

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